Sermorelin
C$47.99
For Research Purposes Only
Sermorelin is a synthetic 29-amino acid peptide, the shortest functional analog of growth hormone-releasing hormone (GHRH). It selectively binds to GHRH receptors in the pituitary gland, stimulating growth hormone (hGH) secretion, which subsequently increases insulin-like growth factor-1 (IGF-1) levels—critical for cell growth, metabolism, and recovery.Key BenefitsStimulates Natural Growth Hormone Production – Unlike synthetic hGH, Sermorelin promotes endogenous hGH release, supporting balanced hormonal regulation.Enhances Muscle Growth and Metabolism – Increased IGF-1 levels may boost muscle development, fat metabolism, and overall recovery.Minimal Endocrine Disruption – Sermorelin targets GHRH receptors without significantly altering other hormonal markers like prolactin, insulin, cortisol, or thyroid hormones.Short Half-Life for Controlled Activity – With an estimated half-life of 11–12 minutes. Sermorelin induces pulsatile hGH release, mimicking natural secretion patterns.
Quantity
Molecular Makeup
Molecular Makeup
Molecular Formula: C149H246N44O42S
Molecular Weight: 3357.93 g/mol
Other Known Titles: GRF 1-29
Refrence
Prakash, A, and K L Goa. “Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.” BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy vol. 12,2 (1999): 139-57. https://pubmed.ncbi.nlm.nih.gov/18031173/
Koutkia, Polyxeni et al. “Growth hormone-releasing hormone in HIV-infected men with lipodystrophy: a randomized controlled trial.” JAMA vol. 292,2 (2004): 210-8. https://pubmed.ncbi.nlm.nih.gov/15249570/
Vitiello, Michael V et al. “Growth hormone releasing hormone improves the cognition of healthy older adults.” Neurobiology of aging vol. 27,2 (2006): 318-23. https://pubmed.ncbi.nlm.nih.gov/16399214/
Research Insight
Sermorelin is a synthetic 29-amino acid peptide that binds to growth hormone-releasing hormone (GHRH) receptors, triggering intracellular signaling pathways. It is hypothesized to increase cyclic adenosine monophosphate (cAMP) levels, activating protein kinase A (PKA), which promotes growth hormone (hGH) secretion from the pituitary gland. This in turn enhances insulin-like growth factor-1 (IGF-1) synthesis, a critical mediator of growth, metabolism, and cellular repair.
Key Benefits
- Promotes Growth & Development – In growth hormone deficiency models, Sermorelin increased growth velocity over 12 months, with sustained effects for 36 months.
- Enhances Muscle & Fat Metabolism – Research indicates an 82% rise in hGH and a 107% increase after 16 weeks, supporting muscle growth and fat reduction.
- Supports Cognitive Function – Studies suggest Sermorelin enhances cognitive performance, particularly in aging populations, by influencing neural processing related to memory and learning.
- Potential Anti-Tumor Properties – Preliminary findings propose that Sermorelin may inhibit tumor cell proliferation, possibly interfering with cancer cell cycles.
- Hormonal Regulation in Hypogonadism – Research suggests Sermorelin stimulates FSH and LH, potentially increasing testosterone production in test models.
- Lipodystrophy & Body Composition – Clinical trials in HIV-positive subjects demonstrated improved lean body mass and reduced visceral fat with no significant impact on glucose or insulin levels.
This version maintains scientific precision while highlighting the peptide’s key benefits in an accessible format. Let me know if you’d like further refinements!