Selank
C$85.99
For Research Purpose Only
Selank Peptide: Overview and Benefits
Scientific Summary
Selank is a synthetic heptapeptide designed to mimic Tuftsin, a natural immunoregulatory peptide. It consists of a Tuftsin sequence at the N-terminus and a Pro-Gly-Pro (PGP) sequence at the C-terminal, enhancing its potential to cross biological barriers, including the blood-brain barrier. Research suggests Selank modulates neurotransmitter activity and gene expression, contributing to neuroprotection, mood stabilization, and immune regulation.
This peptide blend is provided for research and laboratory use only. Please review and adhere to our Terms and Conditions before ordering.
Quantity
Molecular Makeup
- Molecular Formula: C33H57N11O9
- Molecular Weight: 751.88 g/mol
- Other Names: TP-7, Selanc
Research Insights
Key Benefits
- Boosts Brain Function: Increases brain-derived neurotrophic factor (BDNF) expression, supporting cognitive function and neuroplasticity.
- Enhances Mood and Anxiety Regulation: Modulates serotonin metabolism, potentially alleviating mood disorders and stress-related conditions.
- Supports Relaxation: Influences GABAergic activity, reducing neuronal excitability and promoting anxiolytic effects.
- Regulates Inflammation: Modifies CX3CR1 gene expression, potentially controlling inflammatory processes.
- Improves Stress Response: May inhibit enkephalin degradation, prolonging the effects of opioid peptides involved in stress and pain regulation.
Memory & Cognitive Function
- Enhances learning: Improves conditioned avoidance response (CAR) in murine models, reducing errors and increasing correct responses.
- Supports neural adaptation: Modulates neuropeptide systems, strengthens synaptic stability, and promotes neuroplasticity.
- Reduces anxiety-related cognitive impairment: May enhance memory consolidation by minimizing stress-related disruptions.
Immunomodulation
- Regulates immune response: Increases IL-6 cytokine levels and modifies Th1/Th2 ratios, potentially optimizing immune system function.
Withdrawal Management
- Alleviates alcohol withdrawal symptoms: Reduces behavioral disruptions in ethanol-dependent murine models within 48 hours.
Cardiovascular Health
- Lowers blood pressure: Decreases arterial blood pressure by 32% within minutes.
- Improves cerebral circulation: Increases cerebral blood flow by 24%, supporting brain oxygenation.
Metabolic & Weight Regulation
- Reduces cholesterol & fat: Lowers LDL, VLDL, and triglycerides by 25–58%, promoting healthier lipid profiles.
- Enhances glucose metabolism: Improves fat metabolism and maintains stable blood glucose levels.
- Prevents weight gain: Maintains weight in high-fat diet models, potentially aiding weight management.
Selank's neuroprotective, anxiolytic, and immune-modulating properties make it a promising candidate for further research into neurological and metabolic conditions.
Reference
Fridkin M, Stabinsky Y, Zakuth V, Spirer Z. Tuftsin and some analogs: synthesis and interaction with human polymorphonuclear leukocytes. Biochim Biophys Acta. 1977 Jan 24;496(1):203-11. https://pubmed.ncbi.nlm.nih.gov/576412/
Kozlovskaya MM, Kozlovskii II, Val'dman EA, Seredenin SB. Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress. Neurosci Behav Physiol. 2003 Nov;33(9):853-60. https://pubmed.ncbi.nlm.nih.gov/14969422/
Elena Filatova et al., GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells. https://doi.org/10.3389/fphar.2017.00089
Volkova, A., Shadrina, M., Kolomin, T., Andreeva, L., Limborska, S., Myasoedov, N., & Slominsky, P. (2016). Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Frontiers in pharmacology, 7, 31. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757669/