PT-141
C$97.99
For Research Purposes Only
PT-141 Peptide: Scientific Overview
Bremelanotide (PT-141) is a synthetic cyclic peptide composed of seven amino acids. It acts as an agonist to melanocortin receptors, mimicking the natural hormone alpha-MSH. Derived from melanotan II metabolism, PT-141 is primarily researched for its role in reproductive function and neurochemical regulation.
Mechanism of Action
PT-141 selectively activates MC3R and MC4R receptors in the central nervous system (CNS):
MC3R, located in the hypothalamus, is linked to energy regulation, appetite control, and metabolic functions such as glucose and lipid metabolism.
MC4R plays a crucial role in appetite suppression, energy expenditure, and reproductive function, particularly influencing penile tissue response.
Potential Effects
Enhanced Sexual Function – Studies suggest PT-141 may increase neurochemical signaling linked to sexual arousal.
Metabolic Modulation – MC3R and MC4R activation may contribute to weight regulation and appetite control.
CNS Stimulation – PT-141 may trigger neuronal activity within the hypothalamus, influencing sexual motivation in test models.
Quantity
Molecular Makeup
Molecular formula: C50H68N14O10
Molecular weight: 1025.18 g/mol
Other Known Titles: Bremelanotide
Clinical Insight
PT-141 Peptide: Scientific Overview and Potential Benefits
Selective Action in Sexual Behavior
PT-141 (Bremelanotide) is a synthetic melanocortin agonist that primarily interacts with MC3R and MC4R receptors in the central nervous system (CNS). Early studies in murine models indicate it enhances sexual arousal without altering general motor functions or reflexive sexual behaviors. Researchers suggest that PT-141 selectively stimulates melanocortin receptor activity, influencing neural pathways linked to sexual motivation.
Key Benefits
Enhances Sexual Desire – In animal studies, PT-141 increased solicitation behaviors, indicating targeted activation of neural networks involved in sexual response.
Supports Erectile Function – Activation of MC4R may stimulate nitric oxide (NO) production, which facilitates vasodilation and cavernosal pressure, potentially improving erectile response.
CNS Engagement – PT-141 appears to activate hypothalamic and limbic brain regions, influencing dopaminergic signaling in areas associated with sexual motivation.
Mechanism and Neurochemical Impact
Studies suggest PT-141 triggers neuronal activation in the hypothalamus, leading to enhanced neural communication and increased sexual responsiveness. Research has proposed that PT-141 might influence dopamine terminals in specific brain regions, though further studies are needed for confirmation.