NAD+
C$110.00
For Research Purpose Only
NAD+ Peptide: Scientific Overview and Benefits
Nicotinamide Adenine Dinucleotide (NAD+) is a vital coenzyme involved in metabolism, energy production, DNA repair, and cellular signaling. Synthesized from components like tryptophan, NMN, and NR, NAD+ supports over 500 enzymatic reactions, including redox functions via NADH conversion. It also regulates key enzymes such as sirtuins (SIRTs), PARPs, and cADPRS, which maintain mitochondrial health, genomic stability, and immune response.
This peptide is provided for research and laboratory use only. Please review and adhere to our Terms and Conditions before ordering.
Quantity
Molecular Makeup
Molecular Formula: C21H27N7O14P2
Molecular Weight: 663.43 g/mol
Other Known Titles: nicotinamide adenine dinucleotide
Research Insights
Key Benefits
Promotes Healthy Aging
- Improves metabolism: Enhances energy production, reduces weight gain, and optimizes lipid profiles in aging models.
- Increases physical activity: Boosts overall vitality and physiological function.
Supports Brain Health
- Restores mitochondrial function: Rejuvenates oxygen consumption and ATP synthesis in neurodegenerative models.
- Enhances cognitive resilience: Mitigates the effects of mitochondrial dysfunction in nerve and brain cells.
Facilitates DNA Repair
- Protects DNA integrity: Improves repair mechanisms during ischemic stress through PARP activation and NAD+ replenishment.
- Maintains genomic stability: Supports single-strand DNA break repair while preventing NAD+ depletion during stress.
Liver & Kidney Health
- Protects liver function: Prevents obesity and alcoholic hepatitis while improving glucose homeostasis.
- Enhances kidney resilience: Activates SIRT pathways to protect against glucose-induced hypertrophy and cisplatin-induced kidney damage.
Skeletal & Cellular Function
- Boosts ATP production: Increases mitochondrial energy output, supporting muscle function.
- Reduces inflammation: Modulates oxidative stress, improving cellular health.
- Optimizes metabolism: Facilitates glycolysis and the citric acid cycle, ensuring efficient energy conversion.
NAD+ demonstrates potential across metabolism, neuroprotection, and cellular repair, underscoring its importance in productive aging and overall health. NAD+ also plays a vital role in energy regulation, organ protection, and metabolic efficiency, making it a key focus for further research.
Reference
Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P., & Bohr, V. A. (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in molecular medicine, 23(10), 899–916. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494058/
Braidy N, Liu Y. NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis. Exp Gerontol. 2020 Apr;132:110831. https://pubmed.ncbi.nlm.nih.gov/31917996/
Heer C, et al, Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity. Journal of Biological Chemistry. Volume 295, Issue 52, Dec 2020. https://www.jbc.org/article/S0021-9258(17)50676-6/fulltext