N-Acetyl Semax Amidate
C$78.00
For Research Puposes Only
N-Acetyl Semax Peptide: Scientific Overview and Benefits
Mechanism of Action
N-Acetyl Semax is a synthetic polypeptide derived from adrenocorticotropic hormone (ACTH). It contains Met-Glu-His-Phe and a Pro-Gly-Pro (PGP) extension, which enhances its ability to penetrate the blood-brain barrier (BBB) via lipid raft-mediated endocytosis and receptor-mediated transcytosis. Acetylation increases resistance to enzymatic degradation, prolonging its half-life and bioavailability.
Key Benefits
- Cognitive Enhancement – May improve memory, focus, and learning capacity through modulation of dopamine, serotonin, and BDNF levels.
- Neuroprotection – Potentially stabilizes neuronal function, reducing oxidative stress and protecting brain cells.
- Mood Regulation – Increases serotonergic activity, possibly alleviating anxiety and stress-related symptoms.
- Pain and Stress Management – Inhibits enkephalin degradation, which may enhance natural pain relief and stress adaptation.
- Immune Support – Suggested to modulate gene expression, improving immune system efficiency
Quantity
Molecular Makeup
Molecular Formula: C37H51N9O10S
Molecular Weight: 858.97 g/mol
Other known titles: ACTH (4-7)PGP, HY-P1146
Research Insights
Scientific Overview
N-Acetyl Semax is a synthetic ACTH-derived polypeptide with neuroprotective and nootropic properties. It enhances blood-brain barrier (BBB) permeability, serotonin metabolism, and dopaminergic signaling, promoting cognitive function and stress resilience.
Mechanism of Action
- Modulates neurotransmitters – Increases serotonergic activity and dopaminergic response, improving mood and cognition.
- Supports brain repair – Enhances neuronal recovery in models of ischemic stroke.
- Regulates immune function – Modifies cytokine levels, potentially improving immune defense.
Key Benefits
- Enhances memory & focus – Supports learning efficiency and attention span.
- Reduces anxiety & stress – Shown to alleviate anxiety-related behaviors, including maternal separation effects.
- Supports cardiovascular health – May help prevent heart failure post-myocardial infarction.
- Aids neuroprotection – Research suggests improvements in brain activity following strokes.