Kisspeptin-10
C$81.99
For Research Use Only
Kisspeptin-10 is a bioactive peptide derived from the KISS1 gene, responsible for encoding a 145-amino acid precursor protein. This precursor undergoes enzymatic cleavage, first forming Kisspeptin-54, which is further processed into Kisspeptin-10 (residues 45-54)—a critical regulator of reproductive hormone signaling.Kisspeptin-10, derived from the KISS1 gene, is a 10-amino acid fragment of a 54-amino acid peptide involved in reproductive regulation. It acts as a ligand for the G-protein coupled receptor 54 (GPR54), modulating the hypothalamic-pituitary-gonadal axis by stimulating GnRH release and influencing gonadotropin secretion.
Kisspeptin-10, derived from the KISS1 gene, is a 10-amino acid fragment of a 54-amino acid peptide involved in reproductive regulation. It acts as a ligand for the G-protein coupled receptor 54 (GPR54), modulating the hypothalamic-pituitary-gonadal axis by stimulating GnRH release and influencing gonadotropin secretion.
Food Intake Regulation
Kisspeptin-10, distributed across brain regions including the hypothalamus, impacts appetite regulation. Studies on mice suggest its potential to reduce meal frequency and total meal time while maintaining meal size and eating rate. This action may be mediated by modulating neuropeptide Y (NPY) and brain-derived neurotrophic factor (BDNF) expression in hypothalamic cells, elevating NPY while suppressing BDNF. Additionally, Kisspeptin-10 may lower serotonin and dopamine levels, influencing hunger and feeding behaviors.
Quantity
Molecular Makeup
Molecular Formula: C63H83N17O14
Molecular Weight: 1302.4 g/mol
Other Known Titles: Kisspeptin 45-54
Research Insights
Mechanism of Action
Kisspeptin-10, derived from the KISS1 gene, regulates gonadotropin-releasing hormone (GnRH), influencing reproductive function, hormone release, and neuroprotection. It interacts with GPR54 receptors, modulating various physiological processes.
Key Benefits
- Regulates Reproductive Hormones – Influences FSH and LH secretion, potentially aiding pubertal development and fertility.
- Enhances Emotional Response – Modulates limbic brain activity, increasing responsiveness to sexual and bonding stimuli.
- Supports Metabolic Function – Impacts food intake regulation, possibly reducing meal frequency while maintaining normal appetite control.
- Provides Neuroprotection – Potentially reduces amyloid-beta and alpha-synuclein toxicity, supporting cognitive health.
- Aids Hormonal Development – May help manage hypogonadotropic hypogonadism (HH) and polycystic ovarian syndrome (PCOS) by correcting hormonal imbalances.
Refrence
essager, S., Chatzidaki, E. E., Ma, D., Hendrick, A. G., Zahn, D., Dixon, J., Thresher, R. R., Malinge, I., Lomet, D., Carlton, M. B., Colledge, W. H., Caraty, A., & Aparicio, S. A. (2005). Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proceedings of the National Academy of Sciences of the United States of America, 102(5), 1761–1766. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC545088/
Mead, E. J., Maguire, J. J., Kuc, R. E., & Davenport, A. P. (2007). Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system. British journal of pharmacology, 151(8), 1143–1153. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189831/
omninos, A. N., Wall, M. B., Demetriou, L., Shah, A. J., Clarke, S. A., Narayanaswamy, S., Nesbitt, A., Izzi-Engbeaya, C., Prague, J. K., Abbara, A., Ratnasabapathy, R., Salem, V., Nijher, G. M., Jayasena, C. N., Tanner, M., Bassett, P., Mehta, A., Rabiner, E. A., Hönigsperger, C., Silva, M. R., Dhillo, W. S. (2017). Kisspeptin modulates sexual and emotional brain processing in humans. The Journal of clinical investigation, 127(2), 709–719. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272173/
This peptide blend is provided for research and laboratory use only. Please review and adhere to our Terms and Conditions before ordering.