Ipamorelin
C$57.99
For Research Pupose Only
| Ipamorelin Peptide Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) classified as a Growth Hormone Secretagogue (GHS). It selectively binds to ghrelin (GHS-R1a) receptors on the pituitary, stimulating growth hormone (GH) release without significantly affecting prolactin or ACTH levels. Enhanced GH secretion promotes IGF-1 synthesis, lipolysis, cellular proliferation, and anabolic effects on muscle and bone. Ipmorelin peptide is available for research and laboratory purposes only. Please review and adhere to our Terms and Conditions before ordering. |
Quantity
Molecular Makeup
Chemical Profile
- Molecular Formula: C₃₈H₄₉N₉O₅
- Molecular Weight: 711.86 g/mol
- Alternate Names: NNC 26-0161
Research Insights
Research and Clinical Findings
- Selective Agonism & GH Synthesis:
Ipamorelin activates GHS receptors on somatotrophs, triggering phospholipase C (PLC) activation, which increases inositol triphosphate (IP₃) release and DAG production. This raises intracellular calcium and activates protein kinase C (PKC), stimulating GH exocytosis. Clinical trials have demonstrated a robust GH increase—up to 80 mIU/L, approximately a 60-fold elevation over placebo.
- Bone Tissue:
In murine models assessed by dual X-ray absorptiometry (DEXA) and pQCT, Ipamorelin enhances bone mineral content (BMC) and cortical cross-sectional area, while volumetric bone mineral density (BMD) remains unchanged, suggesting improved bone growth without altering density ratios.
- Gastrointestinal Function:
Ipamorelin accelerates gastric emptying in surgically induced delayed transit models and enhances smooth muscle contractility, likely via synergistic interactions with ghrelin signaling pathways.
- Appetite and Weight Regulation:
Through its ghrelin-mimicking mechanism, Ipamorelin increases appetite, leading to approximately 15% weight gain in experimental models. This effect is associated with increased fat-pad deposition and elevated serum leptin levels, suggesting a role in energy homeostasis.
- Anabolic Action and Nitrogen Balance:
Ipamorelin improves anabolic status, evidenced by a roughly 20% reduction in urea-N synthesis (CUNS) during catabolic conditions, likely through modulation of urea cycle enzyme expression and restoration of nitrogen balance.
Reference
Lall, S., Tung, L. Y., Ohlsson, C., Jansson, J. O., & Dickson, S. L. (2001). Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues. Biochemical and biophysical research communications, 280(1), 132–138. https://doi.org/10.1006/bbrc.2000.406
Jiménez-Reina, L., Cañete, R., de la Torre, M. J., & Bernal, G. (2002). Influence of chronic treatment with the growth hormone secretagogue Ipamorelin, in young female rats: somatotroph response in vitro. Histology and histopathology, 17(3), 707–714. https://doi.org/10.14670/HH-17.707